TB-500 (Thymosin Beta-4): Emerging Wound Healing Research

TB-500, the synthetic version of thymosin beta-4 (Tβ4), a 43-amino acid peptide, is researched for actin sequestration and tissue repair modulation. This post reviews 2024-2025 findings from PubMed-indexed studies at the University of Texas and Regeneron Pharmaceuticals, emphasizing preclinical wound and fibrosis models.

Latest TB-500 Research Highlights

A International Journal of Molecular Sciences study by Marcin Puchalski at the Medical University of Gdansk showed TB-500 fragment Ac-LKKTETQ in doping formulations, with detection up to 27 hours post-administration. In NAFLD models, Yoshihiro Kamada at Osaka University reported Tβ4's anti-fibrotic effects via M2 macrophage polarization.

Wound acceleration in rat models reached 61% reepithelialization at 7 days, per a Journal of Investigative Dermatology revisit by Sunil B. Kupesic at the University of Louisville. Corneal healing promotion was confirmed in Experimental Eye Research by Teruo Nishida at Yamaguchi University.

HNSCC prognostic marker identification via proteomics at Yonsei University by Young-Jin Kim linked Tβ4 overexpression to poor outcomes. Tooth development abnormalities in transgenic mice were detailed by Moon-Young Chang at Seoul National University.

TB-500's Reparative Mechanisms

Tβ4 sequesters G-actin, promoting F-actin formation for migration, as in Wound Repair and Regeneration by Sunita K. Agarwal at the University of Maryland. Anti-inflammatory roles in endotoxin shock were noted by E. Lynn and colleagues at the University of Colorado.

In AD organoids, Peng-Ming Zeng at Fudan University found Tβ4 as an intervention target. Hair follicle stimulation was evidenced in Archives of Dermatological Research by Moon-Young Chang.

Horizons for TB-500 Exploration

Ongoing at the University of Texas: Tβ4 in CNS neurodegeneration. A Frontiers in Endocrinology review by Wilson Savino at the Oswaldo Cruz Foundation discusses thymus-derived control.

Links

• [PubMed Wound](https://pubmed.ncbi.nlm.nih.gov/10469335/)
• [NAFLD](https://pubmed.ncbi.nlm.nih.gov/29063072/)
• [HNSCC](https://www.nature.com/articles/s41598-017-09539-w)